Ctrl+Alt+Del is a gaming webcomic by professional web-cartoonist Tim Buckley. Wikipedia points out that since inception, "The comic's focus has gradually shifted away from single strip gags towards longer story arcs and greater continuity." Also, Tim has been able to stay financially afloat by adding a fee-based members-only features and publishing a book. Ctrl+Alt+Del is currently updated on a Monday, Wednesday, Friday, and Saturday schedule.
The comics focus on Ethan and Lucas:
"Ethan currently works in a video game store called Game Haven. Lucas works tech support at a local computer shop. Scott is a freelance web designer. The other characters have jobs as well."(FAQ)
It's super game-nerd-core, which means to understand the comics, you have to either be (physically or spiritually) a 15 year old adolescent or have lived in close proximity to one. Enjoy.
(From Wikipedia, Guy)